Evaluation of a recombinant parasite antigen for the diagnosis of lymphatic filariasis.
Identifieur interne : 00C850 ( Main/Exploration ); précédent : 00C849; suivant : 00C851Evaluation of a recombinant parasite antigen for the diagnosis of lymphatic filariasis.
Auteurs : S. Dissanayake [États-Unis] ; H. Zheng ; G. Dreyer ; M. Xu ; L. Watawana ; G. Cheng ; S. Wang ; P. Morin ; B. Deng ; L. KurniawanSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1994.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Filariose lymphatique (diagnostic), Humains, Immunoglobuline G (sang), Microfilaria (immunologie), Protéines recombinantes (immunologie), Sérums immuns (immunologie), Test ELISA, Wuchereria bancrofti (immunologie).
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Antigènes d'helminthe, Brugia malayi, Microfilaria, Protéines recombinantes, Sérums immuns, Wuchereria bancrofti.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- Animaux, Humains, Test ELISA.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antigens, Helminth (immunology), Brugia malayi (immunology), Elephantiasis, Filarial (diagnosis), Enzyme-Linked Immunosorbent Assay, Humans, Immune Sera (immunology), Immunoglobulin G (blood), Microfilariae (immunology), Recombinant Proteins (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , immunology : Antigens, Helminth, Immune Sera, Recombinant Proteins.
- diagnosis : Elephantiasis, Filarial.
- immunology : Brugia malayi, Microfilariae, Wuchereria bancrofti.
- Animals, Enzyme-Linked Immunosorbent Assay, Humans.
Abstract
We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from approximately 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.
PubMed: 8024066
Affiliations:
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Le document en format XML
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Dissanayake</name><affiliation wicri:level="2"><nlm:affiliation>Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Tropical Public Health, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Zheng, H" sort="Zheng, H" uniqKey="Zheng H" first="H" last="Zheng">H. Zheng</name></author><author><name sortKey="Dreyer, G" sort="Dreyer, G" uniqKey="Dreyer G" first="G" last="Dreyer">G. Dreyer</name></author><author><name sortKey="Xu, M" sort="Xu, M" uniqKey="Xu M" first="M" last="Xu">M. Xu</name></author><author><name sortKey="Watawana, L" sort="Watawana, L" uniqKey="Watawana L" first="L" last="Watawana">L. Watawana</name></author><author><name sortKey="Cheng, G" sort="Cheng, G" uniqKey="Cheng G" first="G" last="Cheng">G. Cheng</name></author><author><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S" last="Wang">S. Wang</name></author><author><name sortKey="Morin, P" sort="Morin, P" uniqKey="Morin P" first="P" last="Morin">P. Morin</name></author><author><name sortKey="Deng, B" sort="Deng, B" uniqKey="Deng B" first="B" last="Deng">B. Deng</name></author><author><name sortKey="Kurniawan, L" sort="Kurniawan, L" uniqKey="Kurniawan L" first="L" last="Kurniawan">L. Kurniawan</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immune Sera (immunology)</term><term>Immunoglobulin G (blood)</term><term>Microfilariae (immunology)</term><term>Recombinant Proteins (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Filariose lymphatique (diagnostic)</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Microfilaria (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>Sérums immuns (immunologie)</term><term>Test ELISA</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Immune Sera</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Microfilaria</term><term>Protéines recombinantes</term><term>Sérums immuns</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from approximately 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Cheng, G" sort="Cheng, G" uniqKey="Cheng G" first="G" last="Cheng">G. Cheng</name><name sortKey="Deng, B" sort="Deng, B" uniqKey="Deng B" first="B" last="Deng">B. Deng</name><name sortKey="Dreyer, G" sort="Dreyer, G" uniqKey="Dreyer G" first="G" last="Dreyer">G. Dreyer</name><name sortKey="Kurniawan, L" sort="Kurniawan, L" uniqKey="Kurniawan L" first="L" last="Kurniawan">L. Kurniawan</name><name sortKey="Morin, P" sort="Morin, P" uniqKey="Morin P" first="P" last="Morin">P. Morin</name><name sortKey="Wang, S" sort="Wang, S" uniqKey="Wang S" first="S" last="Wang">S. Wang</name><name sortKey="Watawana, L" sort="Watawana, L" uniqKey="Watawana L" first="L" last="Watawana">L. Watawana</name><name sortKey="Xu, M" sort="Xu, M" uniqKey="Xu M" first="M" last="Xu">M. Xu</name><name sortKey="Zheng, H" sort="Zheng, H" uniqKey="Zheng H" first="H" last="Zheng">H. Zheng</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Dissanayake, S" sort="Dissanayake, S" uniqKey="Dissanayake S" first="S" last="Dissanayake">S. Dissanayake</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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